Francis and Blake Falls are Siamese twins who live in a neat little room in a rundown hotel. While sharing some organs, Blake is always fit and Francis is very sickly. Into their world comes a young lady, who turns their world upside down. She gets involved with Blake, and convinces the two to attend a Halloween party, where they can pass themselves off as wearing a costume. Eventually Francis becomes really ill, and they have to be separated. They then face the physical and mental strains that come from their proposed separation.
When a promised job for Texan Michael fails to materialize in Wyoming, Mike is mistaken by Wayne to be the hitman he hired to kill his unfaithful wife, Suzanne. Mike takes full advantage of the situation, collects the money, and runs. During his getaway, things go wrong, and soon get worse when he runs into the real hitman, Lyle.
A renowned New York playwright is enticed to California to write for the movies and discovers the hellish truth of Hollywood.
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