In the year 2024, the world has collapsed. Grotesque monsters lurk amongst the ruins of Japan, while remaining people scrape together what they can to survive. Kiruko, an odd-job girl in Nakano, accepts a mysterious woman's dying wish to take a boy named Maru to a place called Heaven. Maru is convinced that there will be a boy there who looks exactly like him.
Shōtarō Tatewaki is a normal high school student with a serious demeanor hangs around with Sakurako Kujō. Sakurako is an extraordinarily beautiful woman in her mid-20s from a rich family who loves "beautiful bones." The two live in the city of Asahikawa in Hokkaido, and they get involved in various incidents regarding bones.
Three young girls, strangers to each other, share an instinctual passion and talent for music. Brought together from distinctly different worlds, they meet by chance at the concert of their idol. The concert strikes a chord in each of their hearts and unites them with a common dream of stardom. The girls each enroll in the same music school and are brought together again in a special class for exceptional talent. As their voices come together in harmony, the girls realize that they share more than just a passion for song. A mysterious blue stone, a hauntingly beautiful meoldy... what do these traces of the past have to do with the uncertain future of this gifted trio?
In a future, decimated Earth after the discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies" in order to revive the craft, an event that would result in the utter destruction of all lifeforms on Earth. The protagonists Yu Isami and Hime Utsumiya must utilize a special Antibody called "Brain Powerd" to counter the Orphan plans and save humanity.
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